April 20, 2024


Health know-how

Best Liver Health Supplements – Review Top Liver Detox Pills

Your liver is crucial for health. It detoxifies your body. That’s why supporting your liver health is so important.

The liver is the largest organ inside your body, and it’s about the size of a football. It sits on the right side of your abdomen, just underneath your rib cage.

Because the liver is large and plays such an important role, poor liver health can quickly impact your overall health.

Many people take supplements daily to support liver health. A good liver supplement targets multiple areas of the organ. Some supplements support inflammation. Others help cleanse toxins from your body.

What are the best liver health supplements available today? Which liver health supplements should you buy? Keep reading to discover our guide to the world’s best liver health supplements.

Our Rankings

Our editorial team tested supplements, contacted manufacturers, pored over studies and lab reports, and ultimately compiled the list we see below. Here is our list of the world’s best liver health supplements.

Organifi Liver Reset

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Organifi’s Liver Reset is a popular liver health supplement from one of the internet’s most reputable brands. And, priced at under $28 for a one-month supply, it’s also one of the best-value supplements on this list. Organifi Liver Reset contains liver boosting superfoods like milk thistle, artichoke leaf extract, dandelion root, and Triphala, all of which have been used to support liver health for centuries.

Organifi is transparent with all dosages, making it easy to compare the formula to other liver health supplements sold online. The company also uses organic ingredients, including 300mg of organic Triphala, 300mg of organic dandelion root extract, and 250mg of organic milk thistle seed extract.

Price: $27.95

1MD LiverMD

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1MD LiverMD may be the easiest supplement to buy on this list. You can buy it online through major retailers like Amazon and 1MD.com. You can also find it in stores like Walmart and others. 1MD’s LiverMD is priced at $45 per bottle and contains clinically-studied liver health ingredients like milk thistle extract. The supplement also contains 800mg of NAC, 100mg of ALA, and strong doses of crucial vitamins and minerals like zinc, vitamin E, and selenium.

1MD makes a range of supplements targeting different health and wellness goals, and 1MD’s LiverMD is one of the more popular ones available today. With strong dosages and a doctor-recommended formula, 1MD LiverMD is one of the best liver health supplements you can buy today.

Price: $44.99

Live Conscious LiverWell

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Live Conscious markets their popular LiverWell supplement as a way to enjoy a happy liver and a happy life. The supplement supports liver and metabolism using natural ingredients. By taking two capsules of LiverWell daily, you can purportedly aid liver detoxification and protection, support healthy immune cell production, and support a healthy metabolism, among other benefits.

LiverWell contains ingredients like milk thistle extract, NAC, and ALA, all of which have been linked to liver health. And, at just $26 per bottle, LiverWell is one of the more affordable formulas on this list.

Price: $25.99

Amy Myers MD Liver Support

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Amy Myers MD makes a supplement called Liver Support featuring a blend of ingredients to help detoxify and optimize liver function. The supplement contains 200mg of NAC that acts as a precursor to glutathione. It also contains alpha-lipoic acid to help scavenge free radicals.

Amy Myers MD recommends taking one capsule of Liver Support twice daily to give your body a powerful blend of ingredients to help detox and optimize liver function.

Price: $34.97

Zenith Labs Zenith Detox

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Zenith Detox is a doctor-formulated supplement from Zenith Labs. The supplement claims to support liver health while also supporting healthy phase 1 and 2 detoxification. By taking the capsules daily, you can give your body the ingredients it needs to support healthy liver function and scavenge and eliminate free radicals, among other benefits.

According to the doctor who formulated Zenith Detox, the supplement can give you fewer joint aches, increased physical stamina, a more youthful appearance, and increased confidence, among other benefits we don’t typically see advertised with liver health supplements. Zenith Detox also contains unique ingredients we don’t see with other formulas, including Setria glutathione, L-methionine, and schisandra berry extract.

Price: $49

Gundry MD Complete Liver Support

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Gundry MD’s Complete Liver Support is the most affordable liver health supplement on this list. Priced at under $20 per bottle, Complete Liver Support is marketed as a “Swiss Army knife” for your liver. Gundry MD claims Complete Liver Support can help improve nutrient absorption, support the immune system, support the metabolism, and support your body’s natural defense against environmental toxins, among other benefits.

Complete Liver Support contains a strong dose of an ingredient we don’t see in other supplements listed here: 1,000mg of orange peel extract. Other ingredients in the formula include milk thistle and dandelion.

Price: $19.48

Advanced Bionutritionals Advanced Liver Support

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Advanced Bionutritionals makes an Advanced Liver Support supplement with alpha-lipoic acid (ALA), phosphatidylcholine, milk thistle, selenium, glycyrrhizin, and NAC, among other ingredients.

By taking four capsules of Advanced Liver Support daily, you can purportedly support your brain and liver health, support a healthy inflammation response, and protect your liver against oxidative stress, among other benefits. The supplement is manufactured in the United States using globally sourced ingredients.

Price: $39.95

PureHealth Research Liver Health Formula

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Liver Health Formula from PureHealth Research is a popular supplement formulated by a naturopathic doctor. According to the naturopathic doctor (ND) who created Liver Health Formula, the supplement will “recharge your body’s youth battery” while giving you “unlimited energy, a trim waistline, and sharp thinking,” among other benefits.

Key ingredients in Liver Health Formula include ginger, alfalfa, and beet. It also contains some of the other popular ingredients found in other liver health supplements, including turmeric, dandelion, milk thistle, and artichoke extract.

Price: $49

ActivatedYou Morning Complete

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ActivatedYou Morning Complete is the only supplement on this list not specifically advertised as a liver health supplement. Instead, Morning Complete is an all-in-one daily health supplement. The formula contains prebiotics, probiotics, green superfoods, fiber, and other ingredients to support multiple aspects of your body.

ActivatedYou describes Morning Complete as “a powerful daily wellness drink.” By taking it daily, you can purportedly help your body protect itself against oxidative stressors, support healthy liver and cell function, and support healthy blood sugar, among other benefits.

Price: $79

VitaPost Liver Support Plus

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Priced under $28 per bottle, VitaPost’s Liver Support Plus is one of the more affordable options on our list. Like 1MD’s LiverMD, it’s also one of the few on this list sold through Walmart and other major retailers.

Inside each bottle of Liver Support Plus, you’ll find ingredients like zinc, milk thistle extract, beet, artichoke extract, and celery seed, among others. VitaPost’s Liver Support Plus contains more ingredients – at lower dosages – than other formulas on this list. However, it could support liver health in a small way while offering great value at this price.

Price: $27.95

Phytage Labs Urgent Liver 911

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Urgent Liver 911 is a nutritional supplement from Phytage Labs. The supplement uses ingredients like milk thistle extract, beetroot, artichoke, dandelion, and celery seed, among others, to support liver health in various ways. In fact, the dosages in Urgent Liver 911 are nearly identical to the dosages in Liver Support Plus.

According to Phytage Labs, those who take Urgent Liver 911 daily can give their liver 23 ingredients to support overall liver health. These ingredients can purportedly flush the fat that’s clogging your liver while also detoxifying your liver and reversing damage, among other advertised benefits. At nearly $70 per bottle, Urgent Liver 911 has a much lower value than other liver supplements on this list, which is surprising given the relatively low dosages.

Price: $69.95

Bonus Guide: The Non Alcoholic Fatty Liver Disease Solution

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Supporting your liver isn’t just about taking supplements. It’s also about implementing healthy diet and lifestyle habits. In this bonus guide, Julissa Clay of Blue Heron Health News discusses natural strategies you can use to support liver health in various ways. Blue Heron Health News markets the eBook as a “solution” to non-alcoholic fatty liver disease (NAFLD), a disease caused by the buildup of triglycerides within your liver.

In The Non-Alcohol Fatty Liver Disease Solution, Julissa claims fatty liver disease is “a choice” and “not a prison sentence.” By implementing her recommended treatment program today, you can purportedly “make yourself well again” and “melt away that liver fat,” even if you have a serious case of NAFLD.

Price: $49

How We Ranked

All liver health supplements claim to support the liver in multiple ways. Some of them work as advertised, while others do not. To separate the best and worst liver health supplements, we used the following ranking methods:

Proven Ingredients: The most important thing we looked for in a liver health supplement was the use of proven ingredients. Scientists have published thousands of studies examining how vitamins, minerals, plants, and herbal extracts impact liver health. We preferred supplements that used this body of knowledge to build their formula.

Clinically Effective Dosages: Many liver health supplements contain surprisingly low dosages. Some supplements contain the right ingredients at the wrong dosages. Others contain doses that are far too low to impact the body in any way. We preferred liver health supplements with clinically effective dosages.

Doctor Formulated: Some of the best supplement companies have medical advisory boards with MDs, NDs, and other health professionals. These professionals use their medical experience to create the best liver health supplements. Many of the top-ranked liver health supplements above were formulated by doctors.

Advertised Benefits: Some companies market their liver health supplements with wild health benefits claims. They claim their formula can cleanse the body completely, for example, and eliminate all toxic waste. They claim you can lose 50lbs, look 10 years younger, and cure liver disease by taking their supplement. All of these claims are unrealistic. We preferred liver health supplement companies with honest advertised health benefit claims.

Manufacturer Reputation & Transparency: Some manufacturers have a long history of creating effective supplements. Other manufacturers are new and unestablished. Some manufacturers are transparent with their ingredient sources and manufacturing location. Others are mysteriously vague about this information. We preferred reputable, transparent manufacturers.

Price & Value: Some people want to spend $20 per month on a liver supplement. Others are prepared to spend over $100. Our list includes supplements with all different price ranges, although we emphasized good value at every price range to ensure you were always getting good liver health ingredients per dollar spent.

Liver Health Supplement Benefits: What Does Science Say?

Studies have validated the use of many vitamins, minerals, plants, and herbs for liver health. In fact, some remedies have been used for thousands of years to support liver health. We’ll review some of the best evidence for liver health supplement ingredients below.

Milk thistle is one of the most popular liver health supplement ingredients. Liver health supplements have been used to treat liver disorders for over 2,000 years. Today, most liver health supplements sold in the United States contain milk thistle extract. Milk thistle contains an active ingredient called silymarin. In some lab studies, researchers have found that silymarin helps regenerate liver tissue, support inflammation, and protect liver cells from damage through its antioxidant effects.

Although milk thistle has been shown to support liver health in some studies, it’s been proven less effective in many human studies. In this study, for example, researchers gave milk thistle extract to humans and observed little difference between the milk thistle group and the placebo. Other studies have been more positive, however. This study analyzed the effects of milk thistle extract on children being treated with chemotherapy for leukemia. After 28 days, researchers found that kids in the milk thistle group had slightly less liver damage than kids in the placebo group.

In this 2017 review study, researchers analyzed dozens of trials on milk thistle extract and found that silymarin, the active ingredient in milk thistle extract, affected certain liver enzymes and markers of liver damage in people with liver disease. Similarly, this 2018 Cochrane review found that milk thistle extract’s benefits could help with cirrhosis, hepatitis B, and hepatitis C, all of which are linked to the liver.

Artichoke leaf is another popular liver health supplement ingredient. Like milk thistle, the artichoke leaf seems to work because of its antioxidant properties. Some studies have shown that the antioxidants in artichoke extract can help protect the liver. In one study on animals, researchers found that artichoke leaf helped liver cells regenerate. Meanwhile, this 2018 study found that giving artichoke leaf extract to patients with non-alcoholic fatty liver disease reduced markers of liver damage compared with a placebo, suggesting artichoke leaf could work as advertised to support liver health.

Dandelion root can be found in many liver health supplements listed above. Dandelion, however, is backed by less research than milk thistle extract and artichoke leaf. There have been no large-scale human studies on the effects of dandelion root on liver health. In this 2006 profile on dandelion extract published in the Journal of Ethnopharmacology, researchers found that dandelion root has been studied for its anti-inflammatory, anti-oxidative, and anti-carcinogenic properties, although more research was needed to quantify these properties.

Some liver health supplements contain zinc, an essential mineral needed for immune function, cell division, DNA synthesis, and other crucial functions. If you have chronic liver disease, then you are at a higher risk of developing zinc deficiency. In this 2012 study, researchers found that taking a zinc supplement daily could help protect the liver from oxidative damage caused by hepatitis C viral infections. Outside of this study, however, there have been few major trials analyzing zinc and liver disease.

Licorice root is a popular natural extract found in some liver health supplements. In this 2012 trial, researchers gave licorice root to 379 people with chronic hepatitis C. Participants in the licorice extract group experienced a significant reduction in symptoms of hepatitis C compared to the control group. Meanwhile, a study on rats found that licorice root extract reduced the effects of alcohol-induced inflammation and fat accumulation in the liver. However, more research is needed to verify these benefits in humans. As explained by the National Institutes of Health, heavy consumption of licorice could be unsafe because of high levels of glycyrrhetinic acid, which is why many licorice extract supplements list deglycyrrhizinated licorice (DGL).

Turmeric is one of the most popular supplements for supporting inflammation, and many people take turmeric daily for liver health. Studies show that curcumin, the active ingredient in turmeric, could support liver health in various ways. In this study, for example, researchers found that taking 3g of turmeric daily improved markers of liver health compared to a placebo. Specifically, researchers found that turmeric supplementation significantly reduced serum alanine transaminase (ALT) levels and aspartate aminotransferase (AST) levels without adverse reactions, suggesting that turmeric “may help improve hepatic disorders,” according to researchers.

Yellow dock root is one of the lesser-known liver health supplement ingredients, although studies show it could support liver health in various ways. It’s most commonly found in Essiac tea, a traditional blood cleansing formula used for centuries. Some claim yellow dock root has amazing detoxification powers. Researchers have found that yellow dock root has diuretic effects, which means it increases the frequency of urination, which could help you cleanse waste from your body. It can also stimulate peristalsis and increase the secretion of mucus and water in the colon, improving the rate at which waste is removed from the body. Yellow dock contains active ingredients called anthraquinones, which could make it effective for supporting liver health.

Beetroot, ginger, choline, molybdenum, selenium, alpha-lipoic acid (ALA), and other ingredients have also been linked to liver health in various studies. Some supplements contain a blend of all of these ingredients and more, while others focus on strong dosages of a small number of ingredients.

Signs of Early Liver Problems

Many people have liver problems and don’t know it. Your liver is one of the largest organs in your body. It plays a crucial role in how you feel and perform. If you have poor liver health, it can affect multiple areas of overall health and wellness.

Here are some of the early symptoms associated with a malfunctioning liver:

  • Fatigue, weakness, and tiredness
  • Loss of appetite
  • Unintentional weight loss
  • Nausea and vomiting
  • Dark yellow urine or gray stools
  • Discomfort, stiffness, or pain in the upper right part of the abdomen, just below your ribcage

If you have advanced liver problems, then you could experience more serious symptoms. Signs of advanced liver problems can include bleeding and bruising easily, fluid retention in the abdomen, confusion and cognitive issues, personality and mood changes, jaundice (the yellowing of the eyes and skin), and memory loss.

Liver damage is treatable when caught early. See a doctor if you believe you have liver damage.

Top 7 Ways to Support Liver Health

If you want to support liver health, then a liver health supplement could help. However, diet and lifestyle factors play a bigger role in liver health. By changing your diet and lifestyle habits, you could keep your liver in optimal condition.

Here are some of the best science-backed ways to support liver health:

Reduce Fat: High fat intake can damage your liver, especially when it’s saturated fat. When your blood has high levels of triglycerides and cholesterol, it can create fat deposits around the liver, leading to non-alcoholic fatty liver disease (NAFLD), which is associated with long-term liver damage.

Take a Supplement: Any of the liver health supplements listed above could support liver health in various ways. Some supplements target inflammation. Others help your body cleanse or detoxify itself.

Reduce Alcohol Use: Alcohol is a poison, and your liver metabolizes alcohol to help your body process it. When your liver metabolizes alcohol, it releases toxic chemicals like acetaldehyde. Binge drinking (drinking four to five drinks in two hours or less) can also lead to a liver condition called steatosis, where fat droplets accumulate inside liver cells. Reducing alcohol consumption to a normal range could play a significant role in liver health.

Reduce Smoking: When you smoke, you’re inhaling toxins into your body. Tobacco smoke damages your liver. Your liver filters the toxic substances from your body, creating inflammation and other liver issues.

Reduce Exposure to Toxins: Toxins are all around us. They’re in the air we breathe, the foods and water we consume, and the cleaning products we use. Limiting exposure to toxins can relieve your liver. Your liver must filter these substances. By avoiding toxins, you could support liver health.

Avoid Illegal Drugs: Illegal drugs like heroin and cocaine are directly linked to liver inflammation and damage.

Avoid Overusing Medications: Abusing prescription medications or over-the-counter medications could create liver damage. According to the FDA, several popular drugs could cause liver damage, including antibiotics, acetaminophen, cancer drugs, anti-anxiety drugs, and immunosuppressant drugs. Follow your doctor’s recommended treatment protocol with all of these drugs, and avoid overusing or abusing medications.

FAQs About Liver Health Supplements

Q: What are liver supplements?

A: Liver supplements are natural products that claim to support the health of your liver in various ways.

Q: What is the liver?

A: The liver is a football-sized organ sitting just below your ribcage on the right side of your body. It cleanses toxins from your body and plays a crucial role in overall health and wellness.

Q: What do liver supplements do?

A: Most liver supplements claim to detoxify your liver and kidneys, protect your liver cells against inflammation, optimize your liver’s overall function, and support your immune system, among other benefits.

Q: How do I take liver supplements?

A: Most liver supplements come in the form of a capsule. You take one or two capsules daily as directed. Other liver health supplements come in the form of a powder, and you mix one scoop of the powder with water or the beverage of your choice.

Q: What’s the best liver health supplement?

A: Any of the top-ranked liver health supplements on our list are among the best liver supplements in the world.

Q: What does the liver do?

A: The liver performs several essential functions in the body. It processes nutrients absorbed by the intestines, regulates blood composition to balance proteins, fats, and sugars, destroys old red blood cells, produces essential blood-clotting chemicals, breaks down and metabolizes alcohol and medications, and produces essential proteins and cholesterol, among other functions.

Q: What causes liver damage?

A: Diet and lifestyle factors, overuse of drugs or medications, heavy alcohol usage, smoking, and other factors can all cause liver damage. Diseases like hepatitis can also cause liver damage.

Q: Is liver disease genetic?

A: Some liver disease is genetic, while other liver disease comes from diet and lifestyle factors.

Q: What causes liver damage besides alcohol?

A: Although many people associate alcohol with liver damage, you can also damage your liver through eating uncooked shellfish, overusing medications (like acetaminophen), eating an unhealthy diet, or exposing yourself to chemicals.

Q: What are the signs of liver problems?

A: Signs of liver problems can include fatigue, bloating, gas, constipation, yellow skin or eyes, an inability to lose weight, high blood pressure, mood and depression issues, dark urine, excessive sweating, and poor appetite. Many people with liver problems also bruise more easily.

Q: How do I cleanse my liver?

A: Some people cleanse or detoxify their liver by following a healthy diet for a few days or weeks. Others take supplements. Some just remove toxic foods or habits. You could also drink raw vegetable juice, follow a juice cleanse, or exercise more frequently to help support your body’s ability to cleanse itself.

Q: What are the symptoms of liver disease?

A: Symptoms of liver disease can include fatigue or excessive tiredness, lack of motivation, or itching. As liver disease advances, you may notice symptoms like jaundice (yellowing of the eyes and skin), dark urine, pale or light-colored stool, bleeding from your GI tract, mental confusion and other cognitive issues, and retention of fluids in the abdomen or belly.

Q: How do I know I have liver disease?

A: According to the University of Iowa, approximately 50% of individuals with underlying liver disease have no symptoms. It can be difficult to spot. Talk to your doctor for tests that can help you determine the liver disease.

Q: Can I reverse liver damage?

A: The liver is the only organ in the body that can regenerate itself. With other organs – like the heart – your body replaces the damaged tissue with a scar (just like it repairs skin damage). The liver, however, is able to replace damaged tissue with new cells. According to the University of Iowa, even severe liver damage caused by something like a Tylenol overdose that killed 50 to 60% of liver cells can be repaired completely after 30 days if no complications arise.

Q: Should I take a liver supplement?

A: Your doctor can help you decide if a liver supplement is right for you. Talk to your doctor before taking any supplement, especially if you have liver disease or are taking medication.

Q: What’s the most common cause of liver disease in the United States?

A: The most common cause of liver disease in America is alcohol abuse.

Q: Is the liver the largest organ?

A: The skin is the largest organ, although the liver is the largest organ inside your body.

Q: Is hepatitis a type of liver disease?

A: Yes, hepatitis is a type of liver disease. In fact, the word ‘hepatitis’ translates to ‘inflammation of the liver.

Q: What is cirrhosis?

A: Cirrhosis is late-stage chronic liver disease. Although the liver can generally repair itself, cirrhosis is linked to scarring on the liver (where your body has attempted to repair the liver without regenerating cells). When scar tissue continues to form on the liver, it leads to cirrhosis.

Q: How do doctors test liver health?

A: Doctors may test liver health using a liver function panel, also known as a hepatic function panel. It’s a series of blood tests performed at the same time to detect liver inflammation (hepatitis), liver disease, or other liver damage and liver infections.

Q: Should I perform a liver detox regularly?

A: There’s no evidence that a liver detox can improve the function of your liver. If your liver is healthy, it should already be detoxifying your body. However, healthy diet and lifestyle habits can support your liver’s natural detoxification ability in various ways.

Q: What’s the best diet for liver health?

A: There’s no specific liver health diet. However, doctors often recommend something like the Mediterranean diet to people with liver disease, emphasizing high levels of fruits and vegetables. Doctors may also recommend high-fiber foods, whole-grain breads, and more water consumption. You should avoid foods high in saturated fat, sugar, and salt, including fried foods, while limiting your alcohol and smoking habits.

Q: Do liver supplements work?

A: Some studies have shown that popular ingredients in liver health supplements, including milk thistle, artichoke extract, and turmeric, can genuinely support liver health in various ways. Most of these ingredients work by supporting inflammation within the liver.

Q: Are liver supplements safe?

A: Studies show that liver supplements are safe to take when following the normal recommended dosage. However, talk to your doctor before taking any supplement, especially if you have liver disease or are taking medication.

Q: Can supplements harm my liver?

A: When following the recommended dosages on a supplement, it’s unlikely to impact your liver health. However, studies show that 20% of liver injuries in the United States are linked with herbal dietary supplements.

Q: What is fatty liver?

A: Fatty liver is a reversible condition characterized by the deposit of fat particles (triglycerides) in the cells of the liver. It can be caused by a range of diets, lifestyle, and genetic factors. Fatty liver does not have the potential to lead to cirrhosis.

Q: What is NAFLD?

A: Non-alcoholic fatty liver disease (NAFLD) refers to a range of liver conditions and diseases ranging from minor problems to severe conditions like cirrhosis. All NAFLD conditions have a common symptom: the buildup of fat in the liver.

Final Word

Studies show that milk thistle, artichoke extract, zinc, and other ingredients could help support liver health in various ways. These ingredients have been shown to support inflammation within the liver, help the liver cleanse itself, and support liver health in other ways.

To support the health of your liver, consider taking a liver supplement today. Any of the top-ranked liver health supplements above could help support liver health, detoxification, and cleansing in multiple ways.

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.